Research Associate Professor, IoG Associate Professor of Neurology Medical School Research Scientist, GRECC, VA Medical Center Veterans Affairs Ann Arbor Healthcare System Geriatric Research, Education and Clinical Center VAMC GRECC (11G) 2215 Fuller Road Ann Arbor, MI 48109-2399 Tel: (734) 761-7686 Fax: (734) 761-7489 Email: raymondt@umich.edu

Dr. Turner is a neurologist and neuroscientist interested in neurodegenerative dementias of aging, especially Alzheimer's disease. He participates in clinical studies at the Alzheimer's Disease Research Center and his basic research investigates the molecular mechanisms of Alzheimer’s' disease in cells and transgenic mice.

Publications:

Turner RS, Chervin RD, Frey KA, Minoshima S, Kuhl DE: Probable diffuse Lewy body disease presenting as REM sleep behavior disorder. Neurology 49: 523-527, 1997.

Borg J-P, Yang Y, De Taddeo-Borg M, Margolis B, Turner RS: The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. Journal of Biological Chemistry 273: 14761-14766, 1998.

Yang Y, Turner RS, Gaut JR: The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. Journal of Biological Chemistry 273: 25552-25555, 1998.

Sastre M, Turner RS, Levy E: X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion. Journal of Biological Chemistry 273: 22351-22357, 1998.

Borg JP, Straight SW, Kaech SM, De Taddeo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B: Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. Journal of Biological Chemistry 273: 31633-31636, 1998.

Neelands TR, Greenfield Jr LR, Zhang, J, Turner RS, Macdonald RL: GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells. Journal of Neuroscience 18: 4993-5007, 1998.

Borg JP, Lopez-Figueroa MO, de Taddeo-Borg M, Kroon DE, Turner RS, Watson SJ, Margolis B: Molecular analysis of the X11-mLin-2/CASK complex in brain. Journal of Neuroscience 19: 1307-1316, 1999.

Novak JE, Turner RS, Agranoff BW, Fisher SK: Differentiated human NT2-N neurons possess a high intracellular content to myo-inositol. Journal of Neurochemistry 72: 1431-1440, 1999.

Turner RS, D'Amato CJ, Chervin RD, Blaivas M: The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. Neurology 55: 1730-1723, 2000.

Mueller HT, Borg JP, Margolis B, Turner RS: Modulation of amyloid precursor protein metabolism by X11alpha/mint-1. A deletion analysis of protein-protein interaction domains. Journal of Biological Chemistry 275: 39302-39306, 2000.

Steinhilb ML, Turner RS, Gaut JR: The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-secretase. Journal of Biological Chemistry 276: 4476-4484, 2001.

Gau J-T, Steinhilb ML, Kao TC, D'Amato CJ, Gaut JR, Frey KA, Turner RS: Stable beta-secretase activity and presynaptic cholinergic function during progressive CNS amyloidogenesis in Tg2576 mice. American Journal of Pathology 160: 731-738, 2002.

Hong M, Shah GV, Adams KA, Turner RS, Foster NL: Spontaneous intracranial hypotension causing reversible dementia. Neurology 58: 1285-1287, 2002.

Steinhilb ML, Turner RS, Gaut JR: ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways. Journal of Neurochemistry 80: 1019-1028, 2002.

Ho CS, Marinescu V, Steinhilb ML, Gaut JR, Turner RS, Stuenkel EL: Synergistic effects of Munc18a and X11 proteins on APP metabolism. Journal of Biological Chemistry 277: 27021-27028, 2002.

Corcoran KA, Lu Y, Turner RS, Maren S: Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learning and Memory 9: 243-252, 2002.

King GD, Perez RG, Steinhilb ML, Gaut JR, Turner RS: X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: Mutational analysis of the YENPTY sequence. Neuroscience 120: 143-154, 2003.

Higdon R, Foster NL, Koeppe RA, DeCarli CS, Jagust WJ, Clark CM, Barbas NR, Arnold SE, Turner RS, Heidebrink JL, Minoshima S: A comparison of classification methods for differentiating fronto-temporal dementia from Alzheimer's disease using FDG-PET imaging. Statistics in Medicine 23: 315-326, 2004.

King GD, Cherian K, Turner RS: X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein. Journal of Neurochemistry 88: 971-982, 2004.

Editorials and Reviews

Bieliauskas LA, Turner RS: What Persian Gulf War Syndrome? The Clinical Neuropsychologist 14: 341-343, 2000.

Turner RS: Alzheimer's disease in man and transgenic mice: females at higher risk. American Journal of Pathology 158: 797-801, 2001.

Turner RS, D'Amato CJ, Chervin RD, Blaivas M: The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. Dementia 4: 14-15, 2001.

Turner RS: Idiopathic rapid eye movement sleep behavior disorder is a harbinger of dementia with Lewy bodies. Journal of Geriatric Psychiatry and Neurology 15: 195-199, 2002.

Turner RS: Biomarkers of Alzheimer's disease and mild cognitive impairment: Are we there yet? Experimental Neurology 183: 7-10, 2003.

Hong M, Shah GV, Adams KM, Turner RS, Foster NL: Spontaneous
intracranial hypotension causing reversible frontotemporal dementia.
Dementia 5: 9-11, 2003.

King GD, Turner RS: Adaptor protein interactions: Modulators of amyloid precursor protein metabolism and Alzheimer's disease risk? Experimental Neurology 185: 208-219, 2004.

Book Chapters

Turner RS, Heidebrink JL: Behavioral Neurology. In Labanowski M (ed): Neurology Pearls of Wisdom (Boston Medical Publishing, 1998), 21-28.

Levy E, Sastre M, Turner RS: X11 modulation of beta-amyloid precursor protein cellular stabilization and reduction of amyloid beta-protein secretion. In Iqbal K, Swaab DF, Winblad B, Wisneiwski HM (eds): Alzheimer's Disease and Related Disorders. Etiology, Pathogenesis and Therapeutics (Wiley, Chichester, 1999), 397-404.

Heidebrink JL, Turner RS: Behavioral Neurology. In Labanowski M (ed): Neurology Pearls of Wisdom, 2nd ed. (Boston Medical Publishing, 2001), 21-30.

Hedera P, Turner RS: Inherited Dementias. In Lynch DR, Farmer JM (eds): Neurologic Clinics of North America 20 (Saunders, Philadelphia, 2002), 779-808.

Turner RS: Neurological aspects of Alzheimer's disease. In Lichtenberg PA, Murman DL, Mellow AM (eds): Handbook of Dementia. Psychological, Neurological, and Psychiatric Perspectives (Wiley, Hoboken, N.J., 2003), 1-24.

Heidebrink JL, Turner RS: Behavioral Neurology. In Labanowski M (ed): Neurology Pearls of Wisdom, 3rd ed. (Boston Medical Publishing, 2004), in press.

Turner RS: Alzheimer's disease. In Lynch DR (ed): Neurogenetics: Scientific and Clinical Advances (Dekker, N.Y., N.Y., 2005), in press.

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