Duncan G. Steel, Ph.D. | Institute of Gerontology

Research Professor, IoG
Peter S. Fuss Professor of Engineering
Professor of Electrical Engineering & Computer Science, College of Engineering
Professor of Physics
College of Literature, Science and the Arts

300 N. Ingalls
Ann Arbor, MI 48109-2007
Tel: (734) 936-2143
Fax: (734) 936-2116
Email: dst@umich.edu

**Biophysical studies on the biology of aging.

**Single molecule studies of age related modifcations of HSF1, a protei critical in heat shock factor expression.

**Single molecule studies of the early events of ABeta amyloid formation and the molecular origin of neural toxicity.

Publications:

C.J. Fischer, J.A. Schauerte, A. Gafni, D.G. Steel, "Assessing the stability of mutants of e.coli alkaline phosphatase by monitoring hydrogen exchange kinetics at tryptophan NH sites," Biochemistry 39, pp1455-1461 (2000).

Eric Dirnbach, Duncan Steel, Ari Gafni, "Metal binding and rearrangement: the original of structural annealing in bacterial alkaline phosphatase," Biochemistry 40, pp11219-11226 (2001).

J.R. Guest, T.H. Stievator, B. Orr, E. Tabak, D.G. Steel, D. Gammon, D.S. Katzer, D.Park, Near-field coherent spectroscopy and microscopy of a quantum sytsem: Addressing single eigenstates, Science 293, pp2224-2227 (2001).

C.J. Fischer, J.A. Schauerte, D.G. Steel, A. Gafni, The triplet-state lifetime of indole in aqueous and viscous environments: significance to the interpretation of room temperature phosphorescence in proteins, J. Am. Chem. Soc. 124 pp 10359-10366 (2002).

Jue Shi, Bruce A. Palfey, Joseph Dertouzos, Ari Gafni, and Duncan Steel, Single molecule study of kinetics and mechanism of dihydroorotate dehydrogenase (DHOD), Journal of the American Chemical Society 126 (22:6914-6922 JUN 9 2004