Steven A. Goldstein, Ph.D. | Institute of Gerontology

Research Professor, IoG
Henry Ruppenthal Family Professor of Orthopaedic Surgery and Bioengineering
Professor of Orthopaedic Surgery
Professor of Biomedical Engineering
Professor of Mechanical Engineering
College of Engineering

Room G161, 400 North Ingalls
Ann Arbor, MI 48109-0486
Tel: (734) 936-7417
Fax: (734) 647-0003
Email: stevegld@umich.edu

Dr. Goldstein's research is in the area of orthopaedic science and focuses on connective tissue diseases, their prevention or treatment. Work ranges from fracture repair and total joint replacement to investigating the mechanisms associated with inherited or degenerative connective tissue fragility.

Primary interests:

1. the effects of metabolic or mechanical influences on bone adaptation
2. skeletal fragility associated with aging or degenerative disease
3. functional tissue engineering
4. genetic traits associated with skeletal fragility
5. mechanotransduction
6. structure function properties of connective tissues

New Publications:

McCauley LK, Tozum TF, Kozloff K, Koh-Paige AJ, Chen C, Demashkieh M, Cronovich H, Richard V, Keller ET, Rosol TJ, Goldstein SA: Transgenic Models of Metabolic Bone Disease: Impact of Estrogen Receptor Deficiency on Skeletal Metabolism. Connective Tissue Research, 44(Suppl. 1):250-263. 2003

Volkman SK, Galecki AT, Burke DT, Paczas MR, Moalli, MR, Miller RA, Goldstein SA: Quantitative Trait Loci for Femoral Size and Shape in a Genetically Heterogeneous Mouse Population. J Bone Miner Res, 18(8):1497-1505, 2003.

Tong L, Buchman SR, Ignelzi Jr MA, Rhee S, Goldstein SA: Focal adhesion kinase expression during mandibular distraction osteogenesis: evidence for mechanotransduction. Plastic & Reconstructive Surgery, 111(1):211-222; discussion 223-224, Jan 2003.

Chen H, Frankenburg EP, Goldstein SA, McCauley LK: Combination of Local and Systemic Parathyroid Hormone Enhances Bone Regeneration. Clin Orthop Rel Res, 416:291-302, 2003.

Tarnowski CP, Ignelzi Jr MA, Wang W, Taboas JM, Goldstein SA, Morris MD: Earliest Mineral and Matrix Changes in Force-Induced Musculoskeletal Disease as Revealed by Raman Microspectroscopic Imaging. J Bone Miner Res, 19(1):64-71, 2004.

McCreadie BR, Hollister SJ, Schaffler MB, Goldstein SA: Osteocyte lacuna size and shape in women with and without osteoporotic fracture. J Biomechanics 37(4):563-572, 2004.

Kozloff K, Carden A, Bergwitz C, Forlino A, Uveges T, Morris M, Marini JC, Goldstein SA: Brittle IV mouse model for osteogenesis imperfecta IV demonstrates postpubertal adaptations to improve whole bone strength. J Bone Miner Res, 19(4):614-622, 2004.

Tanck E, Van Donkelaar CC, Jepsen KJ, Goldstein SA, Weinans H, Burger EH, Huiskes R: The mechanical consequences of mineralization in embryonic bone. Bone, 35:186-190, 2004.

Volkman SK, Galecki AJ, Burke DT, Miller RA, Goldstein SA: Quantitative trait loci that modulate femoral mechanical properties in a genetically heterogeneous mouse population. J Bone Miner Res, 19(9):1497-1505, 2004.

Smith-Adaline EA, Volkman SK, Ignelzi Jr. MA, Slade J, Platte S, Goldstein SA: Mechanical environment alters tissue formation patterns during fracture repair. J Orthop Res 22:1079-1085, 2004.

Book:

Guilak F, Butler DL, Goldstein SA, Mooney DJ (eds): Functional Tissue Engineering, Springer-Verlag, New York, Inc. 2003.

Book Chapters:

Goldstein SA: From Concept Towards the Clinic: Preclinical Evaluation of Tissue Engineered Constructs. In: Functional Tissue Engineering. Part VII,, Chapter 29, pp 395-399, Mooney D, Butler D, Goldstein SA, Guilak F (Eds), Springer-Verlag, New York, Inc. 2003.

Goldstein SA: In Situ Tissue Engineering: Localized Delivery of DNA. In: Tissue Engineering in Musculoskeletal Clinical Practice. Chapter 39, pp395-402, Sandell L and Grodzinsky A (Eds), American Academy of Orthopaedic Surgeons, Rosemont, IL.

Evans CH, Goldstein SA, Robbins PD, Baltzer AWA, Lieberman J: Gene Therapy for Bone Regeneration and Repair. In: Bone Regeneration and Repair: Biology and Clinical Applications. Humana Press, (in press).

Novakovic GV, Goldstein SA: Biomechanical Principles of Cartilage and Bone Tissue Engineering. In: Basic Orthopaedic Biomechanics and Mechanobiology, 3rd Edition, Mow VC and Huiskes R (Eds.) Lippincott-Williams and Wilkens (in press).

Miller JD, McCreadie BR, Hankenson KD, Goldstein SA: Bone Form and Function. In: Orthopaedic Basic Science, 3rd Edition, Einhorn T, O'Keefe R, Buckwalter J. AAOS, Rosemont, IL. (in press).