Paul S. Cederna, M.D. | Institute of Gerontology

Assistant Research Scientist, IoG
Assistant Professor of Surgery
Medical School

300 N. Ingalls, Room 1058
Ann Arbor, MI 48109-2007
Tel: (734) 764-9933
Fax: (734) 936-2116
Email: cederna@umich.edu

Paul S. Cederna, M.D., is the Department of Surgery, Associate Chair for Informatics at the University of Michigan Health Systems. He has a dual appointment within the Department of Surgery as an Assistant Professor of Surgery, Plastic Surgery, and within the Institute of Gerontology as an Assistant Research Scientist. His research interests have primarily focused on the mechanisms responsible for skeletal muscle force deficits as a consequence of aging. Over the past 3 years, he has been a Co-PI on an award from the Michigan Life Science Initiative focusing on the adaptive response in skeletal muscle to training and aging with a long-term goal of improving muscle power and mobility in the elderly. Dr. Cederna’s interest in muscle atrophy and weakness leading to frailty and impaired mobility in the elderly has led him to play an integral role in the Muscle Mechanics Laboratory (MML) in the Institute of Gerontology. Declines in skeletal muscle mass and strength impact the quality of life and directly affect the potential for independent living. In addition, the progressive loss of muscle mass and force output as a result of aging limits both the options for and the efficacy of reconstructions for facial paralysis or other motor deficits in the elderly. Academic pursuits within the Institute of Gerontology have included comprehensive evaluations of the basic aspects of muscle physiology, neurobiology, transplant immunology, and recovery of contractile force after skeletal muscle denervation and reinnervation. Ongoing research in the laboratory is aimed at determining the mechanisms responsible for the contractile dysfunction in skeletal muscle observed after denervation and reinnervation, injury, microneurovascular transfer, and aging.

Dr. Cederna is also involved in the tissue engineering initiative within the Institute of Gerontology, playing a prominent role in the scientific advances of the MML over the past year with work focusing on tissue engineering of skeletal muscle and peripheral nerve as relevant to reconstructive surgery. Acellularized constructs of both muscle and nerve have been developed and have been used to produce functional nerve and muscle. Current work is aimed at determining the basic mechanisms that generate cell-matrix interactions and at optimizing function in engineered tissue.

Publications:

J M Rovak, P S Cederna, V Macionis, M S Urbanchek, J H van der Meulen, W M Kuzon. Termino-lateral Neurorrhaphy: The Functional Axonal Anatomy. Microsurgery 20: 6-14, 2000.

M G Urbanchek, J H van der Meulen, P S Cederna, T Eguchi, W M Kuzon. Reinnervated Muscle Force is Related to Muscle Fiber Denervation. Medicine and Science In Sports and Exercise, 32: 324-325, 2000.

S C Haase, P S Cederna, R G Dennis, W M Kuzon. Peripheral Nerve Reconstruction Using Acellular Nerve Grafts. Surgical Forum 51:607-609, 2000.

P S Cederna, M K H Youssef, H Asato, M G Urbanchek, W M Kuzon. Skeletal Muscle Reinnervation By Reduced Axonal Numbers Results In Whole Muscle Force Deficits. Plastic and Reconstructive Surgery 105: 2003-2009, 2000.

S S Jejurikar, W M Kuzon, P S Cederna. The Recurrence of Pyoderma Gangrenosum Within a Chronic Wound After Free Muscle Flap Reconstruction. Journal of Reconstructive Microsurgery 16: 535-539, 2000.

E G Wilkins, P S Cederna, J C Lowery, S Goldfarb, R S Roth, A Perkins, K W Shaheen, P H Izenberg, H Houin. A Prospective Analysis of the Psychosocial Outcomes of Breast Reconstruction: Preliminary Results From The Michigan Breast Reconstruction Outcome Study. Plastic and Reconstructive Surgery 106: 1014-1028, 2000.

P S Cederna, L K Kalliainen, J M Rovak, M G Urbanchek, W M Kuzon. Donor Muscle Structure and Function Following End-to-Side Neurorrhaphy. Plastic and Reconstructive Surgery 107: 789-796, 2001.

E A Krueger, E G Wilkins, M Strawderman, P S Cederna, S Goldfarb, F A Vicini, L J Pierce. Complications and Patient Satisfaction Following Expander/Implant Breast Reconstruction With and Without Radiotherapy. International Journal of Radiation Oncology, Biology, and Physics 49: 713-721, 2001.

P S Cederna, H Asato, X Gu, J van der Meulen, W M Kuzon, B M Carlson, J A Faulkner. Motor Unit Properties of Nerve-Intact Extensor Digitorum Longus Muscle Grafts in Young and Old Rats. Journal of Gerontology-Biologic Sciences 56A, No. 5: B254-B258, 2001.

J Erbella, R Behmand, P S Cederna. A Minimally Invasive Approach to the Correction of Pectus Excavatum. Surgical Laparoscopy, Endoscopy, and Percutaneous Techniques 11, No. 3: 213-217, 2001.

J M Rovak, P S Cederna, W M Kuzon. Termino-lateral Neurorrhaphy: A Comprehensive Review of the Literature. Journal of Reconstructive Microsurgery 17, No. 8: 615-624, 2001.

K Yoshimura, H Asato, S Jejurikar, P S Cederna, M G Urbanchek, W M Kuzon. The Effect of Two Episodes of Denervation and Reinnervation On Skeletal Muscle Contractile Function. Plastic and Reconstructive Surgery 109, No. 1: 212-219, 2002.

G H Borschel, P H Izenberg, P S Cederna. Endoscopically Assisted Reconstruction of Male and Female Poland’s Syndrome. Plastic and Reconstructive Surgery 109, No. 5: 1536-1544, 2002.

K C Chung, P S Cederna. Endoscopic Harvest of Temporoparietal Fascia Free Flaps For Coverage of Hand Wounds. Journal of Hand Surgery 27A: 525-533, 2002.

S Jejurikar, P S Cederna, C Marcelo, W M Kuzon. Aging Promotes Satellite Cell Apoptosis. Journal of the American College of Surgeons 195:3, S46, 2002.

S S Jejurikar, J M Rovak, W M Kuzon, Jr., K C Chung, S V Spilson, P S Cederna. An Evaluation of Elective Plastic Surgery Information on the Internet. Annals of Plastic Surgery 49:5, 460-465, 2002.

S C Haase, J M Rovak, R G Dennis, W M Kuzon, P S Cederna. Recovery of Muscle Contractile Function Following Peripheral Nerve Gap Repair with an Acellularized Peripheral Nerve Graft. Journal of Reconstructive Microsurgery 19:4, 241-248, 2003.

P S Cederna. Message From the Scientific Program Chair. Journal of Reconstructive Microsurgery 19:5, 341-342, 2003.

G H Borschel, K G Wolter, P S Cederna, G A Franklin. Exercise Treadmill Associated Injuries In Children. Journal of Trauma 55(1):130-4, 2003.

J H Van Der Meulen, M G Urbanchek, P S Cederna, T Eguchi, W M Kuzon. Denervated Muscle Fibers Explain the Deficit In Specific Force following Reinnervation of the Rat Extensor Digitorum Longus Muscle. Plastic and Reconstructive Surgery 112:5, 1336-1347, 2003.

D P Bogue, A K Mungara, M Thompson, P S Cederna. Modified Technique For Nipple-Areolar Reconstruction: A Case Series. Plastic and Reconstructive Surgery 112:5, 1274-1275, 2003.

J M Rovak, A Mungara, M A Aydin, P S Cederna. Effects of Vascular Endothelial Growth Factor On Nerve Regeneration in Acellular Nerve Grafts. Journal of Reconstructive Microsurgery 20:1, 53-58, 2004.

J Moni, M Graves, K Griffith, B Frass, E Krueger, P Cederna, L Pierce. Dosimetry Around the Metallic Port Incorporated into Tissue Expanders in Patients Receiving Postmastectomy Radiation Therapy: An Ex Vivo Evaluation. Medical Dosimetry 29(1): 49-54, 2004.

M G Urbanchek, J H Van der Meulen, P S Cederna, T Eguchi, W M Kuzon. Muscle Transfer Force Deficits in Rats is Partially Explained by a Denervated Muscle Fiber Population. Basic and Applied Myology 14(3): 179-189, 2004.

C P Nelson, D A Ohl, P S Cederna. Extraordinary Scrotal Lymphedema After Weight Loss: Resection and Reconstruction of the Giant End-Stage Scrotum. The Journal of Urology 63:6, 1180-1181, 2004.

P S Cederna. Anti CD40 Ligand Antibody Permits Regeneration Through Peripheral Nerve Allografts in a Non-Human Primate Model. By M J Brenner, J N Jensen, J B Lowe, T M Myckatyn, I K Fox, D A Hunter, T Mohanakumar, S E Mackinnon. Invited Discussion in Plastic and Reconstructive Surgery (In Press).

D E Dow, P S Cederna, C A Hassett, T Y Kostrominova, J A Faulkner, R G Dennis. Number of Contractions to Maintain Mass and Force of Denervated Rat EDL Muscles. Muscle and Nerve 30: 77-86, 2004.

C Kauffman, L U Lahoda, P S Cederna, W M Kuzon. Use of Soleus Muscle Flaps for Coverage of Distal Third Tibial Defects. Journal of Reconstructive Microsurgery (In Press).